 |
|
15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
|
 |
|
|
| |
 |
Copyright © 2010.
WCCN2010.COM
All rights reserved |
|
 |
 |
The effect of chocolate with
nuts on hyperglycemia and its
complications in diabetic rat model
Ashraf Abdel- Megeid; Abd El-Rahman
Attia; Omnia Refaat , Hanan Abdel-Mogoud
Nutrition and Food Science
Department, Faculty of Home
Economics, Helwan University, Cairo,
Egypt.
a_2030@hotmail.com |
Background : Recent
data is linking consumption of
flavonoid - rich caccoa products to
the promotion of health
Objective : To
evaluate the beneficial effect of
consuming black chocolate containing
fructose and (almond or hazelnut) on
hyperglycemia and its complications
in diabetic rat model .
Design:
Two main experimental groups were
established: Group 1 (n = 7 rats)
used as a negative control group fed
on basal diet (B S -.). Group 2 (49
rats): injected with alloxan (150
mg/kg body weight) to induce
hyperglycemia and fed on (B.D.),
then this group was divided into
seven subgroups (7 rats each).
Subgroup (1) fed on B.D. (as a
positive control B D + ). Subgroups
(2 & 3) fed on basal diet containing
50 g. and 100g. Chocolate without
nuts/kg diet, respectively. Subgroup
(4 & 5) fed on basal diet containing
50 g. and 100 g. chocolate with
almond/kg diet, respectively.
Subgroup (6 & 7) fed on basal diet
containing 50 g. and 100 g.
chocolate with hazelnut/kg diet,
respectively. The feeding study
continued for 4 weeks then blood
samples were collected for
laboratory investigations.
Results:
Food intake did not change
significantly between all treated
groups, as compared to the (-) and
(+) two control groups . Gain in
body weight expressed in percentage
(BWG %) decreased significantly in
the (+) control , compared with
respective mean value of the (-)
control . Diabetic rats consuming
chocolate – containing diets with or
without nuts showed significant
improvement in BWG%, as compared to
the respective mean value obtained
with (+) control group. All diabetic
rats consuming diets containing
chocolate with or without nuts has
significant lower mean serum glucose
level compared with the respective
mean value in the (+)control.
Consuming of the chocolate
containing diets led also to
significant reductions in the lipid
profile of the liver ; i.e.,
cholesterol, triglycerides, low and
very low density
lipoprotein-cholesterol LDL-c and
VLDL-c , as compared to the (+)
control.The level of high density
cholesterol concentration was the
only lipid parameter, which was
elevated in the liver of the
diabetic rats after consuming the
chocolate containing diet. The
consumption of the chocolate
containing diets led to improvement
of the liver function as evidenced
with lowering in the mean activities
of aspartate amino transferase [AST]
and alanine amino transferase [ALT]
compared to the respective mean
values of the (+) control. The mean
uric acid, urea nitrogen and
creatinine concentrations ;
biomarkers of kidney function were
significantly lower in all diabetic
groups consuming diets containing
chocolate with or without nuts than
the respective mean values found in
the (+) control rats.
Conclusion:
Incorporating of chocolate with nuts
at 10 % in the diet can amelioraten
the pathogenesis associated with
diabetogenesis.
|
|
| |
|
 |
|
:: :: :: :: |
|
