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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Blood
thinning properties of tomato
extract: A dietary alternative to
aspirin in preventing cardiovascular
disease
Asim Duttaroy Norway
Asim Duttaroy,
Depart of Nutrition, Faculty of
Medicine, Univ Oslo, Norway ,
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Hyperactivity of blood platelets and their adhesion and aggregation at the
site of atherosclerotic vessel walls
is the predominant factor in the
pathogenesis of cardiovascular
disease (CVD). In fact,
hyperactivity of platelets as seen
in overweight, diabetes, and other
conditions is primarily responsible
for the development of CVD. Given
the high incidence of cardiovascular
disease there is a great need for
effective and safe anti-platelet
regimen. Moreover, in recent years
aspirin’s anti-platelet limitations
have progressively underscored the
critical need for effective and safe
anti-platelet therapy. This has
stimulated our research for
alternative approach in the
prevention of platelet hyperactivity
in populations such as insulin
resistant, diabetes, overweight etc
who are vulnerable to develop CVD.
Among all the fruits tested, tomato
has the most effective anti-platelet
factors. Most of the anti-platelet
factors reside in the yellow fluid
around the seeds of tomatoes. These
anti-platelet factors are low
molecular weight, water soluble, and
heat stable. These factors in a
dose-dependant manner inhibited
platelet aggregation in vitro.
However, tomato-derived compounds
also inhibit thrombin-induced
platelet aggregation, in contrast to
aspirin. In a randomized,
double-blinded, placebo-controlled
crossover a significant reduction in
platelet aggregation was observed 3h
after supplementation with tomato
extract equivalent to two and six
tomatoes. Two different
extract-supplemented treatment
juices were prepared in 50- and
200-mL volumes. Each treatment juice
contained 18 g tomato extract syrup,
which is equivalent to the quantity
of anti-platelet factors found in 6
fresh tomatoes. Inhibition of
aggregation was observed for both
ADP- and collagen-mediated
aggregation in a dose-dependent
manner. No adverse side effects of
the supplementation were reported,
and no effects on clotting time
variables were detected after
supplementation. Another human trial
indicated its better efficacy and
safety compared with aspirin. Our
data provides numerous evidences
that tomato extracts have great
potential for increasing the
effectiveness of thrombosis
prophylaxis through an oral tomato
extract therapy. Modulation of
platelet reactivity tomato extract
is now accepted by the EU authority
(EFSA) and permitted as the first
European product to claim blood
thinning property in the packaged
products.
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