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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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The use
of whey protein concentrate in
management of chronic Hepatitis C: A
pilot study
Gamal El-Attar, Zeinab Saleh1,
Safinaz El-Shebini1, Atif Farrag,
Mona M.K. Zoheiry, Azza Hassanien,
Maged El-Ghannam, Shendy Shendy1,
Ehab El-Dabaa, Nariman Zahran
Theodor Bilharz Research
Institute and National Research
Center,Giza Egypt.
gamalalattar@yahoo.com .
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Background: Whey
protein contains a wide range of
biologically active ingredients that
can prevent and attenuate disease.
Objective: To
clarify the effects of oral
administration of whey protein
concentrate (WPC) on viral load and
host defense mechanisms, in
particular, phagocytic function of
neutrophils, selected cytokines and
serum inflammatory markers, in
compensated chronic HCV patients.
Design: twenty
seven HCV patients recruited from
the hepatology clinic of TBRI, and
started the oral supplementation of
WPC twice daily, only 12 patients (9
males, 3 females) had achieved the
study period (8 weeks). Fifteen age
and sex matched healthy participants
were also included, as control
group. Neutrophil phagocytic
activity, serum intercellular
adhesion molecule (sICAM),
interleukin-2 (IL-2), nitric oxide
(NO), as well as HCV-RNA levels and
routine investigations were
determined for patients, before and
after WPC supplementation and once
for controls.
Results: There was
significant decrease in viral load
and markers of active inflammation,
namely; (sICAM, NO, and IL-2),
alanine aminotransferase (ALT) and
aspartate aminotranseferase (AST),
while serum albumin, showed
significant elevation accompanied by
significant improvement in
neutrophil phagocytic activity with
a noticed increase in both total
leucocytic and absolute neutrophil
counts after WPC supplementation
compared to pretreated levels. The
oral WPC supplementation was well
tolerated without any serious
adverse events.
Conclusion: Oral
supplementation of WPC would have
promising results as a new
therapeutic strategy against HCV and
its sequelae by decreasing the viral
load and active inflammation as well
as improving the synthetic capacity
of the liver and the phagocytic
function of neutrophils, in these
patients.
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