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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Omega- 3
polyunsaturated fatty acids [PUFA]
from dietary supplements to medicine
Jan Fedacko1, Daniel
Pella1, P Fedackova1,
J Kmee1 , M Babcak2
1) Pavol Jozef Safarik Faculty of
Medicine and Louis Pasteur
University Hospital, Kosice,
Slovakia
2) Reiman Hospital, Presov, Slovakia
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Although there has been a great
progress in the prevention of
cardiovascular diseases, the
cardiovascular mortality of patients
still remains high. Nearly half of
all cardiovascular deaths in the US
each year is attributed to this
unpredictable and unexpected
complication of AMI. Hence, there is
an urgent medical need for a
targeted therapy to reduce the
incidence of sudden cardiac death.
Since 1980 there have been several
epidemiological and other studies
concerning the benefits of omega -3
polyunsaturated fatty acids ω-3
[PUFA] in cardiovascular health and
prevention. Omega – 3 PUFAs therapy
continues to show great promise in
primary and particularly in
secondary prevention of
cardiovascular diseases.
The most compelling evidence for
cardiovascular benefits of ω-3
[PUFA] comes from 4 controlled
randomized trials with nearly 40,000
participants.
Results from one of the largest
studies , GISSI Prevenzione Trial
show that adding the ω-3 [PUFA]s to
standard therapy of patients who
survived AMI reduced sudden cardiac
death (44 % risk reduction; p=
0.0006). In addition, significant
decline in all – cause
cardiovascular mortality (21 % risk
reduction, p = 0.0064) further
emphasizes the role of ω-3 [PUFA] in
cardiovascular prevention.
To date , beneficial effects of ω-3
[PUFA ] are attributed to their
antiarrhythmic, lipid lowering ,
antithrombotic and anti-inflammatory
properties.
In conclusion, EPA and DHA improve
the prognosis of cardiovascular
patients in primary and in secondary
prevention of cardiovascular
diseases without any documented side
effects
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