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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Hypoglycemic potency and
other biological activities of the
aqueous extract of
Stevia rebaudiana
leaves ( Bertoni)
*Nabaweya Ibrahim, **EL-Gengaihi, S
Reyad S, ***Nagy, S.EL.Regal. *Pharmacognosy
Dept., ** Medicinal and Aromatic
Plants and medicinal chemistry Depts;
National Research Center , Giza,
Dokki .
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Stevia rebaudiana Leaves is a a non-caloric natural sweet herbs
alternative to artificially produced
sugar substitutes, native to Brazil
and Paraguay. In the present study,
eight sweet diterpene glycosides
were quantitavely identified in the
aqueous lyophilized extract using
HPLC analysis and identified using
internal standard .The hypoglycemic
effect of the aqueous extract was
evaluated in diabetic rats by
treatment with Stevia extract
(2.5g/kg B. Wt) for a period of 21
days caused a significant decrease
in the blood glucose levels of
diabetic rats (-32.98%), as compared
to the diabetic control rats. A
significant decrease in the levels
of serum fasting glucose (-43.12),
blood glycated hemoglobin (HbA1) (-
60.68 %,) urea (-8.9%), creatinine
(-30.10%) total cholesterol
(-39.05%) total lipids (-42.07%) and
ALT (-38.16%) and AST (-69.19%) were
observed. Also aqueous extract
caused non significant decrease in
sodium levels and significant
increase in potassium level
(55.51%).In diabetic rats the levels
of vitamins C and E were significant
increase, the treatment with aqueous
extract led to a significant
increase of both vitamin C and E
levels vitamin C (90.06.99%) vitamin
E (80.99%), glutathione conc.
(42.58.11%), glutathione peroxidase
(46.79%) and glutathione reductase
(28.84%) in the liver tissues as
compared to diabetic controls.
Histopathological studies of the
present work demonstrated that
treatment of diabetic rats with
aqueous extract had alleviated the
deleterious effects of diabetes on
liver and kidney tissues.
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