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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Serum ghrelin and other
hormones in obese and overweight
children and adolescents
Eman Kamel National Research Center,
Department of Child health, Giza,
Egypt |
Ghrelin hormone is known to play an
important role in glucose metabolism
and in cellular differentiation and
proliferation through growth hormone
(GH) like action.
Objectives: To study the serum
ghrelin level in overweight and
obese children and adolescents, an
additional aim was to study the
relationship between serum levels of
ghrelin hormone and levels of GH,
cortisol, ACTH and glucose. Patients
were divided into 2 groups according
to BMI; Group I consisted of 40
overweight children and adolescence
while group II consisted of 40 obese
and children adolescent. Forty
healthy age and sex matched subjects
were selected as control group. All
groups were subjected to history
taking, clinical examination and
laboratory investigations including
measurement of serum ghrelin level,
GH, cortisol, ACTH and glucose
(fasting and postprandial).
Results : Mean serum ghrelin was
lowest among obese and highest among
the control groups (p< 0.001). Serum
ghrelin correlated negatively with
BMI in the obese (group II) only and
it was associated with low GH and
high cortisol levels. In overweight
and/or obese children and
adolescents, the correlation of
serum ghrelin with the blood glucose
and ACTH levels was not significant
(P>0.05). A negative correlation was
found between serum ghrelin and BMI
in obese group and it was associated
with low GH and high cortisol
levels.
Conclusion: Overweight and obese
children and adolescents were
characterized with low serum ghrelin
level . Accurate and appropriate
assessment of overweight and obesity
in children and adolescents was
recommended and further studies
should be done on the important role
of ghrelin in managing the
complications
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