15th World Congress Clinical Nutrition

19th – 22nd September 2010  El Sokhna Resort -  Egypt

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Adipose tissue characteristics and control of metabolic syndrome

Priyadarshini Mir, Michael Dodson

Agriculture and Agri-Food Canada,Lethbridge, AB Canada and Washington State University, Pullman Washington USA.

Objective of the study: To determine the effect of monthly or a single feed withdrawal (at age = 140d) treatments for 48h on adipocyte number and glucose tolerance in castrated pigs was investigated

Design of the experiment: in this experiment using nine pigs per treatment. The glucose tolerance test was conducted at 162 d of age for three pigs in each treatment and the area under the glucose curve (AUC) was determined. At euthanasia, at 180d of age samples of subcutaneous and abdominal adipose tissues were removed and adipocyte number and diameter were determined.

Results: The feed withdrawal regimens led to consistent, although non-significant, increases in adipocyte numbers in the subcutaneous adipose tissue especially for pigs in the single feed withdrawal regimen. However unlike our observations in rats, the abdominal adipocytes were reduced in pigs that underwent the multiple feed withdrawal. The AUC for glucose during the GTT was least for pigs that under went multiple feed withdrawal, but differences between no feed withdrawal and single feed withdrawal did not exist. Although results are different from those observed previously.

Conclusion: data indicate that feed withdrawal can help decrease abdominal adipocyte number and increase subcutaneous numbers and may be able to move fat from abdominal to subcutaneous adipose tissues and providing an opportunity for controlling progression of metabolic syndrome.


   
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