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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Gender specific role of omega-3PUFA
to inhibit platelet microparticle
activity in healthy humans
Melina Phang1, L Lincz1,2,
M.L Garg1
1School of Biomedical
Sciences & Pharmacy, University of
Newcastle; 2Hunter
Haematology Research Group,
Newcastle Mater Hospital, NSW
Australia
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Background:
Activation of platelets results in
the release of microparticles with
known procoagulant activity.
Platelet aggregation occurs upon
activation and is the determining
step leading to a thrombotic event.
Dietary intakes of long chain
omega-3 polyunsaturated fatty acids
(eicosapentaenoic acid, EPA;
docosahexaenoic acid, DHA) have been
shown to reduce platelet
aggregation; however interactions
between microparticle activity and
platelet aggregation are not known.
Objective: To
examine effects of dietary
supplementation with a single dose
of EPA or DHA rich oils on
microparticle activity and platelet
aggregation (ex-vivo) and in males
and females over 24 hours.
Methods: A placebo
controlled trial was conducted in
healthy males and females (n=90).
Microparticle activity was measured
at 0 and 24 hours post
supplementation with either a
placebo or EPA or DHA rich oil.
Results: EPA and
DHA effectively reduced platelet
aggregation at 24 hours post
supplementation relative to placebo
(-13.3 %, P=0.006 and -11.9%,
P=0.016 respectively). Microparticle
activity was reduced following EPA
(-22.6%, P=0.002) only. When grouped
by gender, males showed a reduction
in microparticle activity (-22%,
P=0.018) following EPA, but not DHA
compared with placebo. In females,
DHA significantly reduced platelet
aggregation (-13.7%, P=0.04), while
EPA was not effective. Microparticle
activity was not reduced following
DHA supplementation.
Conclusions:
Significant gender differences exist
to reduce platelet aggregation and
microparticle activity in response
to EPA or DHA. EPA reduces
microparticle activity and platelet
aggregation in males, while in
females DHA reduces platelet
aggregation only.
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