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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Evaluation of herbal
formulation as an effective wound
healing agent in Diabetic foot
ulcers
K Reddy, I Nagaraju, Dattatreya Rao
,C Reddy Depart Anthropology, S.V.
University, Tirupati- India
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Objective: Diabetic foot ulcers
(DFUs), a leading cause of
amputations, affect 15% of people
with diabetes. The main objective of
the study was to evaluate the safety
and healing rates of a herbal
formulation in the treatment of
chronic foot ulcers in diabetic
patients.
Design and Setting: Open label
prospective clinical trial at S.V.
Ayurvedic hospital in Tirupati.
Interventions: The study duration is
45 days. Eight patients (7 males +
one female) were recruited with
secondary failure to standard
medication. Clinical measures
included standard ayurvedic
antidiabetic treatment, daily wound
care including antiseptic bath. The
primary outcome measures were: wound
closure. At the same time, the rate
of ulcer healing, erythema, edema,
scabbing and reepithelialization
were taken as supportive outcome
measures. The target wound's
greatest length and width was
measured at baseline and then every
two weeks till the study duration.
The target wound was also
photographed at baseline and then
every two weeks. Wagner’s grading of
foot lesions was followed to
classify the ulcers. Treatment
consists of an herbal formulation
(oil based) with water soluble
extracts of Azadiracta indica bark,
Glycyrhiza glabra root, Curcuma
longa rhizome further extracted into
Sesamum indicum seed oil (patent
pending), given as topical
application daily once. Treatment
continued after the study duration
till the wound healing upon patient
request.
Results: The mean age of the
patients was 55.37±13.81. The mean
duration of diabetes among the
subjects was 7.25±2.55 years and the
mean ulcer duration was 5.38±2.20
years. Mean ulcer size at baseline
was 83.06±119.33 cm and on 45th day
the size was 26.50±39.72; p<0.196).
Overall there was 68 percent
reduction in ulcer size over a
period of 45 days. The mean scores
on irritation markers like erythema
(09.42±0.66 vs. 05.08±1.02; p<0.05),
edema (08.92±1.11 vs.
0.67±0.61;p<0.05) significantly
reduced and re-epithelialization
(0.83±0.75 vs. 3.00±0.71; p<0.05)
significantly increased between day
zero and day 45. No serious adverse
events were observed.
Conclusion: The herbal adjuvant
therapy was effective in helping the
healing of chronic diabetic ulcers.
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