::.. WCCN 2010 ..::.. Abstracts ..::

15^th World Congress Clinical Nutrition

19^th – 22^nd September 2010 El Sokhna Resort - Egypt

Nutrition, net endogenous acid production, and endocrine-metabolic milieu

Thomas Remer

Research Institute of Child Nutrition, Dortmund, Germany

Elevated net endogenous acid production (NEAP) is a frequent consequence of an unbalanced nutrition with higher intakes of proton-generating protein and insufficient consumption of base-generating fruits and vegetables. Best way to estimate NEAP is quantification of renal net acid excretion (NAE) in 24-h urine samples. High dietary acid loads or high NAE are strong predictors of low grade metabolic acidosis which probably exerts a number of unfavorable endocrine and metabolic effects. This paper focuses on two endocrinologicaly and metabolically relevant outcomes: glucocorticoids and uric acid. Increased cortisol and/or cortisone levels, i.e., an increased glucocorticoid activity may be a direct result of metabolic acidosis and both glucocorticoids and acidosis can be involved in adverse health effects, for example related to the metabolic syndrome. Additionally, changes in renal NAE appear to exert profound influences on the elimination of uric acid for which a contributory role in the development of the metabolic syndrome is strongly assumed too. Therefore, potential effects of diet-dependent NAE on glucocorticoids and uric acid levels will be described and discussed herein.

Scientific Sessions Abstracts

Home :: Register :: Scientific Programme :: About us :: Contact us