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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Regular drinking of boiled ,
filtered or Turkish coffee and its
impact on parameters of relevance to
atherogenicity, liver and kidney
functions in Rat models.
*Amr Rezq and Naglaa, Fathy1
Nutrition & Food Science Department,
Faculty of Home Economics, Helwan
University, Cairo, 1 Home Economic
Department, Faculty of Specific
Education, Suez Canal University,
Port Said, Egypt.
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Coffee (Coffea Arabica) drinking is
the second-largest
worldwide-consumed beverage. Coffee
is rich in chlorogenic acid and
caffeic acid contents; both have
antioxidant activity in vitro.
Coffee preparation in the orient
differs, which may change its
biological activity in different
organs of the body.
Aim of the work: To
evaluate the effect of three types
of coffee beverages on some
biological parameters of
atherogenicity, cardiac, kidney and
liver functions.
Design of the
study: Forty male albino rats were
divided into four groups. The first
group served as control and received
oral saline solution (1.5 ml/100 g
of body weight). Groups 2, 3 and 4
received per 100 grams body weight a
daily oral dose of 1.5 ml of boiled
, filtered or Turkish coffee,
respectively. The biological study
was terminated after six weeks. At
the end of the experiment, blood
samples were collected by cardiac
puncture. The abdomen was opened and
the aorta, kidney and liver were
separated and fixed in 10% formalin.
Results: Oral administration of
boiled , filtered and Turkish,
coffee was associated with
significant decrease in mean body
weights and mean blood glucose
levels. Oral ingestion of boiled and
Turkish coffee increased
significantly the atherogenic index
represented by increase in mean
total lipids, triglycerides, total
cholesterol, LDL-c, and VLDL- c. The
mean values of the above-mentioned
biochemical parameters were quite
comparable among the groups
ingesting filtered coffee and the
respective mean values of the
control group. Oral ingestion of
boiled or Turkish coffee increased
significantly mean total and free
bilirubin and creatinine
concentrations and the serum
activities of alanine amino
transferase (ALT) and aspartic amino
transferase (AST). The rats
receiving filtered coffee didn't
show significant changes in the
above mentioned biochemical
indicators and the mean values were
quite comparable to those of the
control group. The consumption of
the three types of coffee caused
significant increase in blood uric
acid and blood urea nitrogen
concentrations, compared to the
respective control values.
Histopathological examination of the
aorta showed that boiled coffee
induced perivascular leucocytic
cells infiltration; while Turkish
coffee caused perivascular
hemorrhage. Liver section of rats
given orally boiled and Turkish
coffee showed congestion of central
vein and hepatic sinusoids. Boiled
coffee caused hypertrophy and
vacuolations of endothelial lining
glomerular tufts and epithelial
lining renal tubules. Kidney of rats
ingesting Turkish coffee showed
granularity of the cytoplasm of
renal tubular epithelium. However,
kidney of rats ingesting filtered
coffee showed small leucocytic cells
aggregation.
Conclusion: Regular
drinking of boiled or Turkish coffee
could be amongst the risk factors
for cardiovascular diseases as well
as liver and kidney dysfunctions.
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