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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Association of appetite related
hormones with adiopnectin and
insulin in obese and hyperlipidemic
subjects
Mona Sadek, Fatma Khalil, Amal Hamza,
Lamiaa Barakat , Amira Abd El Hamid
Department of Biochemistry &
Nutrition, Girls College, Ain Shams
Univ, Egypt
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Objectives: To
determine the effect of weight
control on selected changes in serum
appetite related hormones and on
insulin resistance among obese males
, who followed an eating weight loss
plan of 5000 kJ/day for 12 weeks.
The main outcomes were blood
glucose, serum insulin insulin
resistance; serum adiponectin;
leptin ; lipids profile and
oxidative stress status. The model
used for estimating cardiovascular
risk is taken from the Framingham
Heart Study . Changes in these
measures were compared across
treatment groups
Results: Obese
males after following a dietary
regimen for weeks lost 15 % of their
body weight. The loss in body weight
was associated with a decrease in
insulin resistance was associated
with a significant increase in serum
adiponectin levels in comparison
with the respective mean values
before treatments. The mean leptin
was elevated the serum of obese
adults before treatments; which was
reduced by approximately 50 % after
following the dietary regimen.
On the other hand, the mean levels
of serum adeponectin and gherlin
were initially low among obese
males, and increased significantly
after completing the dietary
regimen. Initially, the lipid
profile in the serum of the obese
group was characterized with a
significant increase in total
lipids, total cholesterol, LDL-C and
VLDL-C with concomitant significant
decrease in serum HDL-C when
compared with healthy control
subjects. Accordingly, initial the
obese males were at high rish of
developing cardiovascular diseases
based on the high serum free fatty
acid levels [FFAs], atherogenic
index and risk factor (ratio of
LDL-C/ HDL-C). Following the dietary
regimen corrected the lipid profile
to a great extent.
The activities of the antioxidant
enzymes; SOD, CAT & GPx were much
reduced in the blood of obese
subjects compared with respective
mean values among healthy control
subjects. The dietary regimen
susseccfully restored the enzyme
activities to their normal levels
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