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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Impact of consuming some
fermented foods on the risk of colon
cancer induced in female mice.
Mona Sadek*, Rania Mohamed**
*Girls College, Ain Shams University
,**Faculty of science, Seuz Canal
Univ., Egypt |
Fermental foods "containing live
probiotic bacterial strains play a
beneficial role as the dietary
treatment for some health problems
and diseases. One of the effective
meachisms are the anticarcinogenic
factors and enhancing immunity
against the tumor, as well as
stimulate other factors improving
the quality of life.
Aim of the work: Examining the
chemoprotective effect of consuming
probiotics in food matrix on colon
carcinogenicity induced in mice.
Design of the study : Inoculating
the probiotic strains :
Streptococcus thermophilus and
Lactobacillus debrueckii sub sp. At
0.04%w/v in two food preparations
i.e., yoghurt [Y] and fermented
kidney bean (FKB).
Inducing colon carcinogenicity in
female Swiss albino mice. Studying
the impact of oral administration of
the [Y] and [FKB] on selected
biological, biochemical parameters
and histopathological examinations.
Results: Microscopic examination of
colonic tumor sections indicated the
presence of neoplastic mass that
consists of excessive proliferation
with large size and signs of
malignancy. Consuming FKB was the
most effective for lowering number
and size of neoplastic cells with
loss of their nuclei in comparison
with consuming yoghurt which have
also the significant effects against
the degeneration and necrosis of
malignancy. Numerical counts of dead
tumor cells indicated that [Y] or
[FKB] containing diets led to a
decrease in the viability of Ehrlich
ascitis cells and carcinogenesis as
shown in the marked increased of
number of dead tumor cells amounting
to 95.95%, 95.79% and 74.46%, 95.66%
after incubating colons isolated
from mice fed on yoghurt and FKB for
2 and 24hr, respectively.
Consuming [Y] and [FKB] was also
associated with decreasing the risks
of oxidative stress in the
carcinogenic mice as evidenced by
marked increase in the serum levels
of vitamins A, E and selenium as
well as increase in the activity of
erythrocytic super oxide dismutase
(SOD) in association with decreased
serum malondialdhyde (MDA) level.
Hepatic level of reduced glulathion
(GSH) was also increased.
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