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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Short telomeres in
Peripheral white blood cells
predicts for haematological toxicity
in colorectal cancer patients
treated with 5FU
Jennette Sakoff, M
Garg, K Adler, FE Scorgie, LF Lincz
, SP Ackland
Departments of Medical Oncology and
Haematology, Calvary Mater Newcastle
Hospital; Hunter Medical Research
Institute, NSW, Australia
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Colorectal cancer is the most common
type of cancer and while patients
have benefited from recent
therapeutic advances, the use of
more complex treatment regimens has
increased treatment-related
toxicities. Haematological toxicity
is of particular clinical importance
as the resulting decline in
circulating white blood cells leaves
patients prone to infection,
seriously impacting clinical
outcomes. The ability to predict and
then prevent such life-threatening
toxicities remains one of the
greatest challenges of current
cancer care. Our recent discovery
that short telomeres in circulating
blood cells predicts for
chemotherapy induced haematological
toxicity in colorectal cancer
patients is a breakthrough in this
regard1. Telomeres are considered
the biological clock of a cell,
becoming shorter with every cell
division. We have shown that
telomere length in peripheral white
blood cells can be used as a
surrogate measure of telomere length
in haematopoietic stem cells2 and
this is directly related to their
capacity to repopulate the
peripheral circulation3. Thus a
simple blood test can be used to
identify patients most at risk of
haematological toxicity. More
importantly, studies show that
telomeric aging may be reversible,
with the strategy of nutritional and
dietary intervention facilitating
lengthening of telomeres. These
fundamental discoveries pave the way
for the development of novel
preventative measures for colorectal
cancer patients to avoid treatment
associated toxicities.
1. Sakoff et al. TL in PBMNC
predicts for leukopenia, neutropenia
and mucositis in colorectal cancer
patients treated with 5FU. AACR
101st Ann. Meeting, 2010
2. Sakoff et al. TL in haemopoietic
stem cells can be determined from
that of mononuclear blood cells or
whole blood. Leuk. Lymph. 43:2017,
2002
3. Lincz, Scorgie, Sakoff et al. TL
predicts neutrophil recovery in the
absence of G-CSF after autologous
peripheral blood stem cell
transplantation. Bone Marrow Trans.
34:439, 2004
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