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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Chemorotective effect of Coenzyme
Q10 on Lipid levels and Antioxidant
Status in Hyperlipidemic Rats
Hanaa Abd El-Fattah, Nora El-Sheikh,
Mona Sadek ,
Tahany Baumy
Biochemistry and Nutrition
Department, Women's College,
Ain Shams University, Cairo, Egypt
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Study aims The present study aims to
investigate the effect of Coenzyme
Q10 (CoQ10) administration as
antioxidant on oxidative status as
well as the biochemical changes in
lipid profile and some liver
function enzymes of healthy and
hyperlipidemic rats.
Design of the study:
Adult male albino rats (n=64) were
distributed into two groups, one
group was maintained on a healthy
diet, whereby the rest were fed
hyperlipidemic diets for a period of
time. The animals were redistributed
into groups of equal number . One
group was maintained on high fat –
high cholesterol diet [HF-HC] ,
whereby one subgroup received diets
without or containing 90 mg CoQ10 /
kg Diet. At the end of the
experiment (7 weeks) blood samples
were collected for the assay of the
lipid profile ,the antioxidant
status and serum enzymes of liver
function..
Results:In healthy
rats fed a HF-HC diet plus CoQ10,
the lipid profile decreased
significantly (P<0.05) ; whereas the
mean level of high density
lipoprotein-cholesterol (HDL-C) was
elevated. The % decrease averaged
6.8%, 11.3%, 9.1%, 9.1% and 20.8%
for total lipids (TL), total
cholesterol (TC), triacylglycerols
(TAG) very low and low density
lipoprotein-cholesterol (VLDL-C) and
(LDL-C), respectively compared to
respective mean values obtained
among healthy group fed on HF-HC
diet without CoQ10.
Both healthy rats fed on HF-HC diet,
and hyperlipidemic rats fed on
either balanced or HF-HC diet.
consuming diets containing CoQ10
showed significant decrease in mean
serum malondialdehyde (MDA) level.
The incorporation of CoQ10 in the
diet led to significant increase in
the activities of erythrocytic
superoxide dismutase (SOD), hepatic
catalase (CAT) .
Mean reduced glutathione (GSH)level
also increased after consuming diets
containing CoQ10. In all rats fed
balanced or HF-HC diets.
The consumption of diets containing
ConCoQ10 was associated with
significant decrease in the
activities of serum alanine amino
transferases and aspartic amino
transferases by 26.1 and 10.7% in
groups on balanced diets,
respectively. Respective % decrease
of 7.2 and 12.6 % was found among
animal group on HF- HC diet .
Conclusion: CoQ10
showed to be beneficial in the
prevention of the oxidation of low
density lipoprotein by inhibition of
lipid peroxidation. The present
results suggest that CoQ10 can be an
important supplement for patients
with hypercholesterolemia and heart
diseases.
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