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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Increased serum homocysteine levels
are associated with sepsis and
septic shock
1Aysel Aricioglu, 1Elif
Yuksel, 2Melda Aybar
Turkoglu, 2Gulbin
Aygencel Bıkmaz, 1Ahmet
Cumaoglu.
1Gazi University, Faculty
of Medicine, Department of Medical
Biochemistry Ankara TURKEY.
2Gazi University, Faculty
of Medicine Department of Intensive
Care Unit Ankara TURKEY.
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Objective: Septic
shock, the most severe complication
of sepsis, is a deadly disease. In
recent years, exciting advances have
been made in the understanding of
its pathophysiology. Homocystein is
a sensitive marker of folate and
vitamin B12 deficiency. We
investigated hyperhomocysteinemia
and changed nitrit-nitrate levels
may develop in sepsis and septic
shock.
Methods: Total
homocysteine and nitrit-nitrate
concentrations were measured in 41
plasma specimens (15 healty
controls, 10 sepsis patients and 16
septic shock patients). Serum
homocystein levels were determined
with high performance liquid
chromotography assay kit, nitrit-nitrate
levels were measured by colorimetric
assay kit. Summary of results: Serum
homocystein levels were remarkable
increased in both sepsis (p=0.01)
and septic shock (p<0.001) groups.
Serum nitrit-nitrate levels were
significantly increased in septic
shock group (p<0.001) but not in
sepsis (p=0.082) group when compared
with those of controls. When
compared sepsis and septic shock,
there was no significant differences
in homocystein (p=0.065) and nitrit-nitrate
(p=0.453) levels.
Conclution: The
findings indicate that
hyperhomocysteinemia and incresed
nitric oxide levels were associated
with inflamatory sepsis and septic
shock and also vitamin
supplementation may use in these
patients to protect against
hyperhomocysteinemia mediated
pathologies.
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