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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Nutraceuticals with Diuretic
Activity
Hagar El-Bakry, Sahar Al-Okbi,Nagwa
Ammar, Z Hassan, M El-Din, L Abo
ElKassem
National Research Center,
Departments of Nutrition &
Pharmacognosy, Giza, Egypt
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Aim of the work:
studying the diuretic effect of
different nutraceuticals from
selected parts from parsley, olive,
purslane, corn and broad beans.
Methodology: The study included the
effect of oral administration of
these nutraceuticals in 3 different
doses (500, 600 and 750 mg/kg) on
urine volume of rats. Scoping our
work on parsley seeds and olive
leaves, the effect of
co-administration of vitamin C (200
mg/kg) with their functional
components was assessed. Their
saluretic, natriuretic and carbonic
anhydrase inhibition indices was
studied compared to furosemide. The
effect of their long term
administration on serum minerals and
lipids, kidney and liver functions,
nutritional parameters and their
safety through acute toxicity were
assessed.
Results: The
majority of the tested
nutraceuticals produced higher urine
volume compared to control.
Co-administration of vitamin C with
parsley seeds and olive leaves
nutraceuticals increased their
effect on urine volume. Urinary
electrolytes produced by groups
given nutraceuticals from parsley
seeds and olive leaves were
significantly lower than furosemide
but significantly higher than
control. Nutraceuticals from parsley
seed and olive leaves showed a
significant high creatinine
clearance than control. Safety of
these nutraceuticals was confirmed
through acute toxicity test and long
term administration.
Conclusion: The
majority of the tested
nutraceuticals showed diuretic
activity with different degrees.
Vitamin C had synergistic diuretic
action. nutraceuticals from parsley
seed and olive leaves showed
complete safety. The diuretic
activity may be attributed to the
presence of vitamin C, volatile oil,
flavonoids, sterols and the high
Na/K ratio that were identified in
the plants.
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