 |
|
15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
|
 |
|
|
| |
 |
Copyright © 2010.
WCCN2010.COM
All rights reserved |
|
 |
 |
Retinol – binding protein -4. Serum
concentration is correlated with
insulin resistance but not with body
fat in obese non diabetic subjects
Sancia Gaetani, B Guantario, *A
Silvestrini, *E Lombardi, *C Mele,
*A Mordente, D Bellovino, L Mistura
National Research Institute on Food
and Nutrition, Roma and *Institute
of Biochemistry and *Clinical
Biochemistry, Catholic University of
Roma, Italia
|
Obesity has become a global epidemic
and is a major cause of insulin
resistance that provides and early
and strong predictor of type 2
diabetes. Insulin resistance even in
the absence of diabetes, is an
important risk factor for
cardiovascular disease.
Retinol-binding protein-4 (RBP4),
until few years ago only considered
the specific blood carrier of
vitamin A, is now considered also an
adipokine. Increased serum
concentration of RBP4, protein
synthesized mainly in hepatocytes
but also in adipocytes, has been
reported in insulin resistance and
by some authors in human obesity, as
a result of upregulated expression
and increased secretion of the
protein from adipocytes. To assess
whether increased RBP4 concentration
is a precocious marker of insulin
resistance in obesity, RBP4,
transthyretin, glucose, insulin and
other parameters were measured in
serum of obese non diabetic subjects
and in their lean controls. Even
though insulin resistance was found
mainly among obese subjects, this
condition was observed also in
several lean individuals. A strong
positive correlation was found
between RBP4 serum concentration and
insulin resistance, but not between
RBP4 concentration and fat mass. It
is concluded that serum RBP4 is not
a useful marker for assessing the
risk of insulin resistance in
obesity and therefore of developing
in obesity type 2 diabetes.
|
|
| |
|
 |
|
:: :: :: :: |
|
