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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Chemoprotective effects of lipodal
matter of Atriplex Lindleyimoq Moq.
(LINDLEY'S SALTBUCH) on hepato renal
toxicity
Azza A. matloub1, Sahar
S. M. El Souda2 and Manal
A. Hamed3
Departments of 1Pharmacognosy,
2Chemistry of natural
compounds & 3Therapeutic
Chemistry, National Research Center,
Giza , Egypt
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Objective: The work
aimed the detailed description of
the lipoidal profile and hepato-renal
protective effect of Atriplex
lindleyi areal part against
bromobenzene (BB) intoxication in
rats.
Methods Through GC/MS technique, the
unsaponifiable matter and fatty acid
methyl esters from the petroleum
ether (60-800C) extract were
qualitatively and quantitatively
investigated. In vivo examinations
of the petroleum ether extract, five
groups of albino rats were selected
in this study. Group1: normal
control group, group 2: i.p injected
with BB (460mg/kg b.wt) two
times/week for three weeks, group 3:
received oral doses of plant extract
(150mg/kg b.wt.) at the same time
and duration of BB injection. Group
4: served as group 3 and treated
with hepaticum (100 mg/kg b.wt.) as
a reference drug. Group 5: received
plant extract only.
Results Oxygenated
and non-oxygenated hydrocarbons,
alcoholic, phenolic and steroidal
compounds were identified in the
unsaponifiable matter. GC/MS
analysis of fatty acid methyl ester
led to identify 22 compounds.
Drastic changes were observed after
BB intoxication in liver function
enzymes (AST, ALT and ALP), hepatic
cell organelles marker enzymes (SD,
LDH, G-6-Pase, AP and 5`-
nucleotidase), kidney disorder
parameters (creatinine and urea) and
certain antioxidants; glutathione,
lipid peroxide and superoxide
dismutase. Treatment with plant
extract improved all biochemical
parameters under investigation as
well as the histopathological
picture of liver and kidney.
Conclusion, the
lipoidal matter of A. lindleyi
contains bioactive compounds
exhibiting hepato-renal protection.
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