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15th
World Congress Clinical Nutrition
19th
– 22nd September 2010 El Sokhna Resort - Egypt
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Copyright © 2010.
WCCN2010.COM
All rights reserved |
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Anti-ulcer effect of cinnamon and
chamomile aqueous extracts in rat
models
Amr Rezq* and Maysa Elmallh
Nutrition and Food Science
Department, Faculty of Home
Economics, Helwan University.Cairo ,
Egypt
Peptic ulcer is a gastrointestinal
disorder of public health concern.
Pharmaceutical preparations are
expensive and have many side effects
during treatment of any disorder
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Aim of the work: To
evaluate antiulcer potency of
aqueous extracts of cinnamon (CINA)
or chamomile (CHAMO) (100, 200, 300
or 400 mg/kg of body weight) and to
compare the antiulcer potency with
equivalent potency obtained with the
pharmaceutical Zantac ™ (Ranitidine)
drug
Design of the study:
The rat feeding study consisted of
50 male albino rats weighing 160±5g
. Five rats served as positive
control ; another group of five rats
served as standard group. The
remaining 40 rats were divided into
two groups of equal number. The
first group was treated with aqueous
extracts of CINA; whereas the second
group was treated with aqueous
extract of CHAMO. The CINA group was
further divided into four subgroups
given oral dosages of 100, 200, 300
or 400 mg /kg of body weight. The
CHAMO group was divided into four
subgroups treated in an identical
manner as described above . The oral
dosages were given daily via tube
feeding for seven consecutive days.
At the last day of the trial, the
rats were fasted for 24 hours with
access of water. The standard group
was given Zantac (ranitidine)
intraperioteneally (IP) at a dose of
6 mg/100 g body weight, 60 min prior
to the administration of ethanol.
Rats were given oral saline and
aqueous extracts of cinnamon or
chamomile 120 min prior administered
ethanol. Ethanol was administered
orally to all groups at 0.5 ml / 100
g body weight. After 4 hours, all
rats were sacrificed by an overdose
of diethyl ether and their stomachs
removed and washed with saline. The
pH value, the volume of gastric
juice, the ulcer area, and curative
ratio were estimated according to
standard techniques. The stomach was
separated, preserved in formalin
solution (10 %) for subsequent
mounting on paraffin film and
preparation of sections.
Results: The pH
value of the rats with induced
stomach ulcer averaged 4.70±0.26.
The treatment with Zantac ; CINA or
CHAMO was associated with
significant increase in the pH
values compared to the respective
mean value among the positive group.
The mean volume of gastric juice
among the standard (4.30±0.37ml) and
the positive group (4.60±0.52ml) was
almost comparable. Oral
administration of CINA or CHAMO was
associated with significant
reduction in the mean volume of
gastric juice compared to the
respective normal value. Curative
ratios of gastric ulcer were better
in rats given CINA or CHAMO over
those given Zantac. Furthermore,
CHAMO was superior over CINA in its
curative ratios of gastric ulcer.
Histological examination showed
marked necrosis of gastric mucosa
associated with congestion of
submucosal blood vessels, submucosal
edema and hemorrhage in the stomachs
of rats receiving ethanol. The
stomachs of the group receiving
Zantac showed necrosis of gastric
mucosa associated with hemorrhage.
Stomachs of rats treated with CINA
at a dose of 100 mg or 200 mg showed
atrophy of gastric mucosa associated
with submucosal edema . Whereas,
higher CINA dosages of 300 and 400
mg were adequate and
histopathological changes
disappeared from the stomachs . In
the group receiving 100 mg CHAMO ,
there appeared submucosal leucocytic
cells infiltration in the stomachs.
The groups receiving increasing
CHAMO dosages i.e., 200 ,300 or 400
mg showed no histopathological
abnormailities.
Conclusion: Water
extracts of cinnamon and chamomile
had potential antiulcer effect,
which was superior to the respective
effect observed with Zantac.
Chamomile extracts were more
superior to cinnamon in its
chemoprotective effect on the
stomach lining . The antiulcer
curative ratios were dose dependent
with no adverse effects.
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